GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway

Axons fail to regenerate after central nervous system (CNS) injury. Modulation of the PTEN/mTORC1 pathway in retinal ganglion cells (RGCs) promotes axon regeneration after optic nerve injury. Here, we report that AKT activation, downstream of Pten deletion, promotes axon regeneration and RGC surviva...

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Detalles Bibliográficos
Autores principales: Guo, Xinzheng, Snider, William D, Chen, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805534/
https://www.ncbi.nlm.nih.gov/pubmed/26974342
http://dx.doi.org/10.7554/eLife.11903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805534/
https://www.ncbi.nlm.nih.gov/pubmed/26974342
http://dx.doi.org/10.7554/eLife.11903

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