Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

Women live on average longer than men but have greater levels of late-life morbidity. We have uncovered a substantial sex difference in the pathology of the aging gut in Drosophila. The intestinal epithelium of the aging female undergoes major deterioration, driven by intestinal stem cell (ISC) divi...

Descripción completa

Detalles Bibliográficos
Autores principales: Regan, Jennifer C, Khericha, Mobina, Dobson, Adam J, Bolukbasi, Ekin, Rattanavirotkul, Nattaphong, Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805549/
https://www.ncbi.nlm.nih.gov/pubmed/26878754
http://dx.doi.org/10.7554/eLife.10956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805549/
https://www.ncbi.nlm.nih.gov/pubmed/26878754
http://dx.doi.org/10.7554/eLife.10956

Ejemplares similares