Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP(−/−) Mice

Genetic ablation of cellular prion protein (PrP(C)) has been linked to increased neuronal excitability and synaptic activity in the hippocampus. We have previously shown that synaptic activity in hippocampi of PrP-null mice is increased due to enhanced N-methyl-D-aspartate receptor (NMDAR) function....

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Detalles Bibliográficos
Autores principales: Fan, Jing, Stemkowski, Patrick L., Gandini, Maria A., Black, Stefanie A., Zhang, Zizhen, Souza, Ivana A., Chen, Lina, Zamponi, Gerald W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805597/
https://www.ncbi.nlm.nih.gov/pubmed/27047338
http://dx.doi.org/10.3389/fncel.2016.00074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805597/
https://www.ncbi.nlm.nih.gov/pubmed/27047338
http://dx.doi.org/10.3389/fncel.2016.00074

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