The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

Neuronal function is highly sensitive to changes in oxygen levels, but how hypoxia affects dendritic spine formation and synaptogenesis is unknown. Here we report that hypoxia, chemical inhibition of the oxygen-sensing prolyl hydroxylase domain proteins (PHDs), and silencing of Phd2 induce immature...

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Detalles Bibliográficos
Autores principales: Segura, Inmaculada, Lange, Christian, Knevels, Ellen, Moskalyuk, Anastasiya, Pulizzi, Rocco, Eelen, Guy, Chaze, Thibault, Tudor, Cicerone, Boulegue, Cyril, Holt, Matthew, Daelemans, Dirk, Matondo, Mariette, Ghesquière, Bart, Giugliano, Michele, Ruiz de Almodovar, Carmen, Dewerchin, Mieke, Carmeliet, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805856/
https://www.ncbi.nlm.nih.gov/pubmed/26972007
http://dx.doi.org/10.1016/j.celrep.2016.02.047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805856/
https://www.ncbi.nlm.nih.gov/pubmed/26972007
http://dx.doi.org/10.1016/j.celrep.2016.02.047

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