Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein

Phosphatidylinositol 4-kinase beta (PI4KB) is one of four human PI4K enzymes that generate phosphatidylinositol 4-phosphate (PI4P), a minor but essential regulatory lipid found in all eukaryotic cells. To convert their lipid substrates, PI4Ks must be recruited to the correct membrane compartment. PI...

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Detalles Bibliográficos
Autores principales: Klima, Martin, Tóth, Dániel J., Hexnerova, Rozalie, Baumlova, Adriana, Chalupska, Dominika, Tykvart, Jan, Rezabkova, Lenka, Sengupta, Nivedita, Man, Petr, Dubankova, Anna, Humpolickova, Jana, Nencka, Radim, Veverka, Vaclav, Balla, Tamas, Boura, Evzen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806292/
https://www.ncbi.nlm.nih.gov/pubmed/27009356
http://dx.doi.org/10.1038/srep23641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806292/
https://www.ncbi.nlm.nih.gov/pubmed/27009356
http://dx.doi.org/10.1038/srep23641

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