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Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform

A modular p-phosphonated calix[4]arene vesicle (PCV) loaded with paclitaxel (PTX) and conjugated with folic acid as a cancer targeting ligand has been prepared using a thin film-sonication method. It has a pH-responsive capacity to trigger the release of the encapsulated PTX payload under mildly aci...

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Autores principales: Mo, Jingxin, Eggers, Paul K., Yuan, Zhi-xiang, Raston, Colin L., Lim, Lee Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806332/
https://www.ncbi.nlm.nih.gov/pubmed/27009430
http://dx.doi.org/10.1038/srep23489
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author Mo, Jingxin
Eggers, Paul K.
Yuan, Zhi-xiang
Raston, Colin L.
Lim, Lee Yong
author_facet Mo, Jingxin
Eggers, Paul K.
Yuan, Zhi-xiang
Raston, Colin L.
Lim, Lee Yong
author_sort Mo, Jingxin
collection PubMed
description A modular p-phosphonated calix[4]arene vesicle (PCV) loaded with paclitaxel (PTX) and conjugated with folic acid as a cancer targeting ligand has been prepared using a thin film-sonication method. It has a pH-responsive capacity to trigger the release of the encapsulated PTX payload under mildly acidic conditions. PTX-loaded PCV conjugated with alkyne-modified PEG-folic acid ligands prepared via click ligation (fP-PCV(PTX)) has enhanced potency against folate receptor (FR)-positive SKOV-3 ovarian tumour cells over FR-negative A549 lung tumour cells. Moreover, fP-PCV(PTX) is also four times more potent than the non-targeting PCV(PTX) platform towards SKOV-3 cells. Overall, as a delivery platform the PCVs have the potential to enhance efficacy of anticancer drugs by targeting a chemotherapeutic payload specifically to tumours and triggering the release of the encapsulated drug in the vicinity of cancer cells.
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spelling pubmed-48063322016-03-25 Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform Mo, Jingxin Eggers, Paul K. Yuan, Zhi-xiang Raston, Colin L. Lim, Lee Yong Sci Rep Article A modular p-phosphonated calix[4]arene vesicle (PCV) loaded with paclitaxel (PTX) and conjugated with folic acid as a cancer targeting ligand has been prepared using a thin film-sonication method. It has a pH-responsive capacity to trigger the release of the encapsulated PTX payload under mildly acidic conditions. PTX-loaded PCV conjugated with alkyne-modified PEG-folic acid ligands prepared via click ligation (fP-PCV(PTX)) has enhanced potency against folate receptor (FR)-positive SKOV-3 ovarian tumour cells over FR-negative A549 lung tumour cells. Moreover, fP-PCV(PTX) is also four times more potent than the non-targeting PCV(PTX) platform towards SKOV-3 cells. Overall, as a delivery platform the PCVs have the potential to enhance efficacy of anticancer drugs by targeting a chemotherapeutic payload specifically to tumours and triggering the release of the encapsulated drug in the vicinity of cancer cells. Nature Publishing Group 2016-03-24 /pmc/articles/PMC4806332/ /pubmed/27009430 http://dx.doi.org/10.1038/srep23489 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Mo, Jingxin
Eggers, Paul K.
Yuan, Zhi-xiang
Raston, Colin L.
Lim, Lee Yong
Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform
title Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform
title_full Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform
title_fullStr Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform
title_full_unstemmed Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform
title_short Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform
title_sort paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806332/
https://www.ncbi.nlm.nih.gov/pubmed/27009430
http://dx.doi.org/10.1038/srep23489
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