Dual anti-HIV mechanism of clofarabine

BACKGROUND: HIV-1 replication kinetics inherently depends on the availability of cellular dNTPs for viral DNA synthesis. In activated CD4(+) T cells and other rapidly dividing cells, the concentrations of dNTPs are high and HIV-1 reverse transcription occurs in an efficient manner. In contrast, nond...

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Detalles Bibliográficos
Autores principales: Daly, Michele B., Roth, Megan E., Bonnac, Laurent, Maldonado, José O., Xie, Jiashu, Clouser, Christine L., Patterson, Steven E., Kim, Baek, Mansky, Louis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806454/
https://www.ncbi.nlm.nih.gov/pubmed/27009333
http://dx.doi.org/10.1186/s12977-016-0254-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806454/
https://www.ncbi.nlm.nih.gov/pubmed/27009333
http://dx.doi.org/10.1186/s12977-016-0254-0

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