Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway

Berberine (BBR) has been shown to exhibit protective effects against diabetes and dyslipidemia. Previous studies have indicated that BBR modulates lipid metabolism and inhibits hepatic gluconeogensis by decreasing expression of Hepatocyte Nuclear Factor-4α (HNF-4α). However, the mechanism involved i...

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Detalles Bibliográficos
Autores principales: Wei, Shengnan, Zhang, Ming, Yu, Yang, Lan, Xiaoxin, Yao, Fan, Yan, Xin, Chen, Li, Hatch, Grant M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806913/
https://www.ncbi.nlm.nih.gov/pubmed/27011261
http://dx.doi.org/10.1371/journal.pone.0152097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806913/
https://www.ncbi.nlm.nih.gov/pubmed/27011261
http://dx.doi.org/10.1371/journal.pone.0152097

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