Determinants of Cofactor Specificity for the Glucose-6-Phosphate Dehydrogenase from Escherichia coli: Simulation, Kinetics and Evolutionary Studies

Glucose 6-Phosphate Dehydrogenases (G6PDHs) from different sources show varying specificities towards NAD(+) and NADP(+) as cofactors. However, it is not known to what extent structural determinants of cofactor preference are conserved in the G6PDH family. In this work, molecular simulations, kineti...

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Detalles Bibliográficos
Autores principales: Fuentealba, Matias, Muñoz, Rodrigo, Maturana, Pablo, Krapp, Adriana, Cabrera, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807051/
https://www.ncbi.nlm.nih.gov/pubmed/27010804
http://dx.doi.org/10.1371/journal.pone.0152403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807051/
https://www.ncbi.nlm.nih.gov/pubmed/27010804
http://dx.doi.org/10.1371/journal.pone.0152403

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