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Determinants of Cofactor Specificity for the Glucose-6-Phosphate Dehydrogenase from Escherichia coli: Simulation, Kinetics and Evolutionary Studies
Glucose 6-Phosphate Dehydrogenases (G6PDHs) from different sources show varying specificities towards NAD(+) and NADP(+) as cofactors. However, it is not known to what extent structural determinants of cofactor preference are conserved in the G6PDH family. In this work, molecular simulations, kineti...
Autores principales: | Fuentealba, Matias, Muñoz, Rodrigo, Maturana, Pablo, Krapp, Adriana, Cabrera, Ricardo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807051/ https://www.ncbi.nlm.nih.gov/pubmed/27010804 http://dx.doi.org/10.1371/journal.pone.0152403 |
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