Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases

Bruton’s tyrosine kinase (Btk) is a Tec family non-receptor tyrosine kinase that plays a critical role in immune signaling and is associated with the immunological disorder X-linked agammaglobulinemia (XLA). Our previous findings showed that the Tec kinases are allosterically activated by the adjace...

Descripción completa

Detalles Bibliográficos
Autores principales: Chopra, Nikita, Wales, Thomas E., Joseph, Raji E., Boyken, Scott E., Engen, John R., Jernigan, Robert L., Andreotti, Amy H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807093/
https://www.ncbi.nlm.nih.gov/pubmed/27010561
http://dx.doi.org/10.1371/journal.pcbi.1004826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807093/
https://www.ncbi.nlm.nih.gov/pubmed/27010561
http://dx.doi.org/10.1371/journal.pcbi.1004826

Ejemplares similares