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At least two well-spaced samples are needed to genotype a solid tumor
BACKGROUND: Human cancers are often sequenced to identify mutations. However, cancers are spatially heterogeneous populations with public mutations in all cells and private mutations in some cells. Without empiric knowledge of how mutations are distributed within a solid tumor it is uncertain whethe...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807557/ https://www.ncbi.nlm.nih.gov/pubmed/27015839 http://dx.doi.org/10.1186/s12885-016-2202-8 |