Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer

BACKGROUND: Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to occur by sequential accumulation of genetic and molecular alterations able to activate the Ras/Raf/MEK/ERK (MAPK) and/or the PI3K/AK...

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Detalles Bibliográficos
Autores principales: Pappalardo, Francesco, Russo, Giulia, Candido, Saverio, Pennisi, Marzio, Cavalieri, Salvatore, Motta, Santo, McCubrey, James A., Nicoletti, Ferdinando, Libra, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807832/
https://www.ncbi.nlm.nih.gov/pubmed/27015094
http://dx.doi.org/10.1371/journal.pone.0152104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807832/
https://www.ncbi.nlm.nih.gov/pubmed/27015094
http://dx.doi.org/10.1371/journal.pone.0152104

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