HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo

Myxoid sarcoma (MLS) is one of the most common types of malignant soft tissue tumors. MLS is characterized by the FUS-DDIT3 or EWSR1-DDIT3 fusion oncogenes that encode abnormal transcription factors. The receptor tyrosine kinase (RTK) encoding RET was previously identified as a putative downstream t...

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Detalles Bibliográficos
Autores principales: Safavi, Setareh, Järnum, Sofia, Vannas, Christoffer, Udhane, Sameer, Jonasson, Emma, Tomic, Tajana Tesan, Grundevik, Pernilla, Fagman, Henrik, Hansson, Magnus, Kalender, Zeynep, Jauhiainen, Alexandra, Dolatabadi, Soheila, Stratford, Eva Wessel, Myklebost, Ola, Eriksson, Mikael, Stenman, Göran, Stock, Regine Schneider, Ståhlberg, Anders, Åman, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808009/
https://www.ncbi.nlm.nih.gov/pubmed/26595521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808009/
https://www.ncbi.nlm.nih.gov/pubmed/26595521

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