Cooperative therapeutic anti-tumor effect of IL-15 agonist ALT-803 and co-targeting soluble NKG2D ligand sMIC

Shedding of the human NKG2D ligand MIC (MHC class I-chain-related molecule) from tumor cell surfaces correlates with progression of many epithelial cancers. Shedding-derived soluble MIC (sMIC) enables tumor immune escape through multiple immune suppressive mechanisms, such as disturbing natural kill...

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Detalles Bibliográficos
Autores principales: Basher, Fahmin, Jeng, Emily K., Wong, Hing, Wu, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808035/
https://www.ncbi.nlm.nih.gov/pubmed/26625316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808035/
https://www.ncbi.nlm.nih.gov/pubmed/26625316

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