Destabilization of α-Helical Structure in Solution Improves Bactericidal Activity of Antimicrobial Peptides: Opposite Effects on Bacterial and Viral Targets

We have previously examined the mechanism of antimicrobial peptides on the outer membrane of vaccinia virus. We show here that the formulation of peptides LL37 and magainin-2B amide in polysorbate 20 (Tween 20) results in greater reductions in virus titer than formulation without detergent, and the...

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Detalles Bibliográficos
Autores principales: Ulaeto, David O., Morris, Christopher J., Fox, Marc A., Gumbleton, Mark, Beck, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808201/
https://www.ncbi.nlm.nih.gov/pubmed/26824944
http://dx.doi.org/10.1128/AAC.02146-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808201/
https://www.ncbi.nlm.nih.gov/pubmed/26824944
http://dx.doi.org/10.1128/AAC.02146-15

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