Simvastatin Results in a Dose-Dependent Toxic Effect on Spiral Ganglion Neurons in an In Vitro Organotypic Culture Assay

Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an enzyme necessary for the production of mevalonate. They are widely used as cholesterol-lowering drugs. However, conflicting data about the effect of statins on neuronal cells has been published. To explore the effect o...

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Detalles Bibliográficos
Autores principales: Leitmeyer, Katharina, Glutz, Andrea, Setz, Cristian, Wieland, Leonie, Egloff, Sulamith, Bodmer, Daniel, Brand, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808657/
https://www.ncbi.nlm.nih.gov/pubmed/27051663
http://dx.doi.org/10.1155/2016/3580359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808657/
https://www.ncbi.nlm.nih.gov/pubmed/27051663
http://dx.doi.org/10.1155/2016/3580359

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