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Simvastatin Results in a Dose-Dependent Toxic Effect on Spiral Ganglion Neurons in an In Vitro Organotypic Culture Assay

Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an enzyme necessary for the production of mevalonate. They are widely used as cholesterol-lowering drugs. However, conflicting data about the effect of statins on neuronal cells has been published. To explore the effect o...

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Detalles Bibliográficos
Autores principales:	Leitmeyer, Katharina, Glutz, Andrea, Setz, Cristian, Wieland, Leonie, Egloff, Sulamith, Bodmer, Daniel, Brand, Yves
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808657/ https://www.ncbi.nlm.nih.gov/pubmed/27051663 http://dx.doi.org/10.1155/2016/3580359

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