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Antitumor effects of cecropin B-LHRH’ on drug-resistant ovarian and endometrial cancer cells

BACKGROUND: Luteinizing hormone-releasing hormone receptor (LHRHr) represents a promising therapeutic target for treating sex hormone-dependent tumors. We coupled cecropin B, an antimicrobial peptide, to LHRH’, a form of LHRH modified at carboxyl-terminal residues 4–10, which binds to LHRHr without...

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Detalles Bibliográficos
Autores principales: Li, Xiaoyong, Shen, Bo, Chen, Qi, Zhang, Xiaohui, Ye, Yiqing, Wang, Fengmei, Zhang, Xinmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809036/
https://www.ncbi.nlm.nih.gov/pubmed/27021903
http://dx.doi.org/10.1186/s12885-016-2287-0