TGFβ and BMP Dependent Cell Fate Changes Due to Loss of Filamin B Produces Disc Degeneration and Progressive Vertebral Fusions

Spondylocarpotarsal synostosis (SCT) is an autosomal recessive disorder characterized by progressive vertebral fusions and caused by loss of function mutations in Filamin B (FLNB). FLNB acts as a signaling scaffold by linking the actin cytoskleteon to signal transduction systems, yet the disease mec...

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Detalles Bibliográficos
Autores principales: Zieba, Jennifer, Forlenza, Kimberly Nicole, Khatra, Jagteshwar Singh, Sarukhanov, Anna, Duran, Ivan, Rigueur, Diana, Lyons, Karen M., Cohn, Daniel H., Merrill, Amy E., Krakow, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809497/
https://www.ncbi.nlm.nih.gov/pubmed/27019229
http://dx.doi.org/10.1371/journal.pgen.1005936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809497/
https://www.ncbi.nlm.nih.gov/pubmed/27019229
http://dx.doi.org/10.1371/journal.pgen.1005936

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