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Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation

Epithelial-to-mesenchymal transition (EMT) is a malignant cancer phenotype characterized by augmented invasion and metastasis, chemoresistance, and escape from host-immunity. This study sought to identify efficient methods for inducing EMT reversion, to evaluate alterations in chemosensitivity and i...

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Detalles Bibliográficos
Autores principales: KURIMOTO, RYOTA, IWASAWA, SHUNICHIRO, EBATA, TAKAHIRO, ISHIWATA, TSUKASA, SEKINE, IKUO, TADA, YUJI, TATSUMI, KOICHIRO, KOIDE, SHUHEI, IWAMA, ATSUSHI, TAKIGUCHI, YUICHI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809654/
https://www.ncbi.nlm.nih.gov/pubmed/26984042
http://dx.doi.org/10.3892/ijo.2016.3419