Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration

Mutations in the glucosidase, beta, acid (GBA1) gene cause Gaucher’s disease, and are the most common genetic risk factor for Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) excluding variants of low penetrance. Because α-synuclein-containing neuronal aggregates are a defining feature o...

Descripción completa

Detalles Bibliográficos
Autores principales: Davis, Marie Y., Trinh, Kien, Thomas, Ruth E., Yu, Selina, Germanos, Alexandre A., Whitley, Brittany N., Sardi, Sergio Pablo, Montine, Thomas J., Pallanck, Leo J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809718/
https://www.ncbi.nlm.nih.gov/pubmed/27019408
http://dx.doi.org/10.1371/journal.pgen.1005944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809718/
https://www.ncbi.nlm.nih.gov/pubmed/27019408
http://dx.doi.org/10.1371/journal.pgen.1005944

Ejemplares similares