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Identification of an orally available compound with potent and broad FLT3 inhibition activity

FLT3 internal tandem duplication (FLT3-ITD) is an activating mutation found in 20%-30% of patients with acute myeloid leukemia (AML), which makes FLT3 an attractive target for the treatment of AML. Although FLT3-mutant patients respond to current FLT3 inhibitors, relapse usually happens due to the a...

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Detalles Bibliográficos
Autores principales: Chen, Yun, Guo, Yao, Zhao, Wanke, Tina Ho, Wan-Ting, Fu, Xueqi, Joe Zhao, Zhizhuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809803/
https://www.ncbi.nlm.nih.gov/pubmed/26411368
http://dx.doi.org/10.1038/onc.2015.362