The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease

Polycystin-1 (PC1) plays an essential role in renal tubular morphogenesis, and PC1 dysfunction causes human autosomal dominant polycystic kidney disease. A fundamental characteristic of PC1 is post-translational modification via cleavage at the juxtamembrane GPCR proteolysis site (GPS) motif that is...

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Detalles Bibliográficos
Autores principales: Trudel, Marie, Yao, Qin, Qian, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810088/
https://www.ncbi.nlm.nih.gov/pubmed/26805887
http://dx.doi.org/10.3390/cells5010003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810088/
https://www.ncbi.nlm.nih.gov/pubmed/26805887
http://dx.doi.org/10.3390/cells5010003

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