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MLL5 maintains spindle bipolarity by preventing aberrant cytosolic aggregation of PLK1
Faithful chromosome segregation with bipolar spindle formation is critical for the maintenance of genomic stability. Perturbation of this process often leads to severe mitotic failure, contributing to tumorigenesis. MLL5 has been demonstrated to play vital roles in cell cycle progression and the mai...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810297/ https://www.ncbi.nlm.nih.gov/pubmed/27002166 http://dx.doi.org/10.1083/jcb.201501021 |