Fast antibody fragment motion: flexible linkers act as entropic spring

A flexible linker region between three fragments allows antibodies to adjust their binding sites to an antigen or receptor. Using Neutron Spin Echo Spectroscopy we observed fragment motion on a timescale of 7 ns with motional amplitudes of about 1 nm relative to each other. The mechanistic complexit...

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Detalles Bibliográficos
Autores principales: Stingaciu, Laura R., Ivanova, Oxana, Ohl, Michael, Biehl, Ralf, Richter, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810366/
https://www.ncbi.nlm.nih.gov/pubmed/27020739
http://dx.doi.org/10.1038/srep22148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810366/
https://www.ncbi.nlm.nih.gov/pubmed/27020739
http://dx.doi.org/10.1038/srep22148

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