Identification of a Fragment-Based Scaffold that Inhibits the Glycosyltransferase WaaG from Escherichia coli †

WaaG is a glycosyltransferase that is involved in the biosynthesis of lipopolysaccharide in Gram-negative bacteria. Inhibitors of WaaG are highly sought after as they could be used to inhibit the biosynthesis of the core region of lipopolysaccharide, which would improve the uptake of antibiotics. He...

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Detalles Bibliográficos
Autores principales: Muheim, Claudio, Bakali, Amin, Engström, Olof, Wieslander, Åke, Daley, Daniel O., Widmalm, Göran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810412/
https://www.ncbi.nlm.nih.gov/pubmed/27025525
http://dx.doi.org/10.3390/antibiotics5010010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810412/
https://www.ncbi.nlm.nih.gov/pubmed/27025525
http://dx.doi.org/10.3390/antibiotics5010010

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