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One-pot synthesis and in-vitro anticancer evaluation of 5-(2′-indolyl)thiazoles

A series of 5-(2′-indolyl)thiazoles were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of thioamides 3 with 3-tosyloxypentane-2,4-dione 4 led to in situ formation of 5-acetylthiazole 5 which upon treatment with arylhydrazines 6 in polyphospho...

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Detalles Bibliográficos
Autores principales: Vaddula, Buchi Reddy, Tantak, Mukund P., Sadana, Rachana, Gonzalez, Michael A., Kumar, Dalip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810428/
https://www.ncbi.nlm.nih.gov/pubmed/27021742
http://dx.doi.org/10.1038/srep23401