The Ec-NhaA antiporter switches from antagonistic to synergistic antiport upon a single point mutation

The Na(+), Li(+)/H(+) antiporter of Escherichia coli (Ec-NhaA) maintains pH, Na(+) homeostasis in enterobacteria. We used isothermal titration calorimetry to perform a detailed thermodynamic analysis of Li(+) binding to Ec-NhaA and several of its mutants. We found that, in line with the canonical al...

Descripción completa

Detalles Bibliográficos
Autores principales: Dwivedi, Manish, Sukenik, Shahar, Friedler, Assaf, Padan, Etana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810432/
https://www.ncbi.nlm.nih.gov/pubmed/27021484
http://dx.doi.org/10.1038/srep23339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810432/
https://www.ncbi.nlm.nih.gov/pubmed/27021484
http://dx.doi.org/10.1038/srep23339

Ejemplares similares