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Evolutionary reversion of live viral vaccines: Can genetic engineering subdue it?
Attenuated, live viral vaccines have been extraordinarily successful in protecting against many diseases. The main drawbacks in their development and use have been reliance on an unpredictable method of attenuation and the potential for evolutionary reversion to high virulence. Methods of genetic en...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811365/ https://www.ncbi.nlm.nih.gov/pubmed/27034780 http://dx.doi.org/10.1093/ve/vev005 |