The Roles of Histidines and Charged Residues as Potential Triggers of a Conformational Change in the Fusion Loop of Ebola Virus Glycoprotein

Ebola virus (EBOV) enters cells from late endosomes/lysosomes under mildly acidic conditions. Entry by fusion with the endosomal membrane requires the fusion loop (FL, residues 507–560) of the EBOV surface glycoprotein to undergo a pH-dependent conformational change. To find the pH trigger for this...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jinwoo, Gregory, Sonia M., Nelson, Elizabeth A., White, Judith M., Tamm, Lukas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811418/
https://www.ncbi.nlm.nih.gov/pubmed/27023721
http://dx.doi.org/10.1371/journal.pone.0152527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811418/
https://www.ncbi.nlm.nih.gov/pubmed/27023721
http://dx.doi.org/10.1371/journal.pone.0152527

Ejemplares similares