Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability

Here, we report a novel non-epigenetic function of histone deacetylase (HDAC) 8 in activating cancer stem cell (CSC)-like properties in breast cancer cells by enhancing the stability of Notch1 protein. The pan-HDAC inhibitors AR-42 and SAHA, and the class I HDAC inhibitor depsipeptide, suppressed ma...

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Detalles Bibliográficos
Autores principales: Chao, Min-Wu, Chu, Po-Chen, Chuang, Hsiao-Ching, Shen, Fang-Hsiu, Chou, Chih-Chien, Hsu, En-Chi, Himmel, Lauren E., Huang, Han-Li, Tu, Huang-Ju, Kulp, Samuel K., Teng, Che-Ming, Chen, Ching-Shih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811498/
https://www.ncbi.nlm.nih.gov/pubmed/26625202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811498/
https://www.ncbi.nlm.nih.gov/pubmed/26625202

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