Cargando…

Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability

Here, we report a novel non-epigenetic function of histone deacetylase (HDAC) 8 in activating cancer stem cell (CSC)-like properties in breast cancer cells by enhancing the stability of Notch1 protein. The pan-HDAC inhibitors AR-42 and SAHA, and the class I HDAC inhibitor depsipeptide, suppressed ma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chao, Min-Wu, Chu, Po-Chen, Chuang, Hsiao-Ching, Shen, Fang-Hsiu, Chou, Chih-Chien, Hsu, En-Chi, Himmel, Lauren E., Huang, Han-Li, Tu, Huang-Ju, Kulp, Samuel K., Teng, Che-Ming, Chen, Ching-Shih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811498/ https://www.ncbi.nlm.nih.gov/pubmed/26625202

Ejemplares similares

Retraction: Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability
por: Chao, Min-Wu, et al.
Publicado: (2020)

Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines
por: Lee, Su-Lin, et al.
Publicado: (2013)

Epigenetic regulation of NOTCH1 and NOTCH3 by KMT2A inhibits glioma proliferation
por: Huang, Yin-Cheng, et al.
Publicado: (2017)

A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells
por: Chou, Chih-Chien, et al.
Publicado: (2015)

Targeting the Oncogenic E3 Ligase Skp2 in Prostate and Breast Cancer Cells with a Novel Energy Restriction-Mimetic Agent
por: Wei, Shuo, et al.
Publicado: (2012)

HDAC Inhibition Decreases the Expression of EGFR in Colorectal Cancer Cells
por: Chou, Chia-Wei, et al.
Publicado: (2011)

Function of Integrin-Linked Kinase in Modulating the Stemness of IL-6–Abundant Breast Cancer Cells by Regulating γ-Secretase–Mediated Notch1 Activation in Caveolae()()
por: Hsu, En-Chi, et al.
Publicado: (2015)

Sensitivity of osteosarcoma cells to HDAC inhibitor AR-42 mediated apoptosis
por: Murahari, Sridhar, et al.
Publicado: (2017)

Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer
por: Wei, Tzu-Tang, et al.
Publicado: (2015)

Blood Reflux-Induced Epigenetic Factors HDACs and DNMTs Are Associated with the Development of Human Chronic Venous Disease
por: Chang, Shun-Fu, et al.
Publicado: (2022)

Epigenetic Modification and Differentiation Induction of Malignant Glioma Cells by Oligo-Fucoidan
por: Liao, Chien-Huang, et al.
Publicado: (2019)

H3K23/H3K36 hypoacetylation and HDAC1 up-regulation are associated with adverse consequences in obstructive sleep apnea patients
por: Chen, Yung-Che, et al.
Publicado: (2021)

Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor
por: Liva, Sophia G, et al.
Publicado: (2020)

Pin1 Is Involved in HDAC6-mediated Cancer Cell Motility
por: Chuang, Hsiang-Hao, et al.
Publicado: (2018)

Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer Cells
por: Lee, Jane Ying-Chieh, et al.
Publicado: (2016)

Pin1 coordinates HDAC6 upregulation with cell migration in lung cancer cells
por: Chuang, Hsiang-Hao, et al.
Publicado: (2020)

Deltex1 is inhibited by the Notch–Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation
por: Cheng, Yi-Chuan, et al.
Publicado: (2015)

Unraveling the Pathogenesis of Asthma and Chronic Obstructive Pulmonary Disease Overlap: Focusing on Epigenetic Mechanisms
por: Chen, Yung-Che, et al.
Publicado: (2022)

Epigenetically maintained SW13+ and SW13- subtypes have different oncogenic potential and convert with HDAC1 inhibition
por: Davis, McKale R., et al.
Publicado: (2016)

Epigenetics: A Potential Mechanism Involved in the Pathogenesis of Various Adverse Consequences of Obstructive Sleep Apnea
por: Chen, Yung-Che, et al.
Publicado: (2019)

Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression
por: Huang, Yen-Sung, et al.
Publicado: (2016)

Numerical analysis of airflow alteration in central airways following tracheobronchial stent placement
por: Ho, Chien-Yi, et al.
Publicado: (2012)

BCAS2 Regulates Delta-Notch Signaling Activity through Delta Pre-mRNA Splicing in Drosophila Wing Development
por: Chou, Meng-Hsuan, et al.
Publicado: (2015)

The HDAC Inhibitor LBH589 Induces ERK-Dependent Prometaphase Arrest in Prostate Cancer via HDAC6 Inactivation and Down-Regulation
por: Chuang, Mei-Jen, et al.
Publicado: (2013)

Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells
por: Tay, Rong En, et al.
Publicado: (2020)

Titers and breadth of neutralizing antibodies against SARS-CoV-2 variants after heterologous booster vaccination in health care workers primed with two doses of ChAdOx1 nCov-19: A single-blinded, randomized clinical trial
por: Chuang, Chih-Hsien, et al.
Publicado: (2022)

Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer
por: Ding, Li-Yun, et al.
Publicado: (2020)

Krüppel-like factor 10 modulates stem cell phenotypes of pancreatic adenocarcinoma by transcriptionally regulating notch receptors
por: Tsai, Yi-Chih, et al.
Publicado: (2023)

Lung tumorigenesis induced by human vascular endothelial growth factor (hVEGF)-A(165) overexpression in transgenic mice and amelioration of tumor formation by miR-16
por: Tung, Yu-Tang, et al.
Publicado: (2015)

White Matter Abnormalities Correlating with Memory and Depression in Heroin Users under Methadone Maintenance Treatment
por: Lin, Wei-Che, et al.
Publicado: (2012)

Potential antidepressant effects of a dietary supplement from Huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice
por: Chou, Ming-Yu, et al.
Publicado: (2023)

Requirement of HDAC6 for activation of Notch1 by TGF-β1
por: Deskin, Brian, et al.
Publicado: (2016)

HDAC3 functions as a positive regulator in Notch signal transduction
por: Ferrante, Francesca, et al.
Publicado: (2020)

Comparison of the Diagnostic Accuracies of Monocyte Distribution Width, Procalcitonin, and C-Reactive Protein for Sepsis: A Systematic Review and Meta-Analysis
por: Huang, Yu-Hsuan, et al.
Publicado: (2023)

The Novel HDAC8 Inhibitor WK2-16 Attenuates Lipopolysaccharide-Activated Matrix Metalloproteinase-9 Expression in Human Monocytic Cells and Improves Hypercytokinemia In Vivo
por: Jan, Jing-Shiun, et al.
Publicado: (2017)

Suppression of Tumor Growth and Muscle Wasting in a Transgenic Mouse Model of Pancreatic Cancer by the Novel Histone Deacetylase Inhibitor AR-42()()
por: Henderson, Sally E., et al.
Publicado: (2016)

Exposure to Heavy Metals and Serum Adiponectin Levels among Workers: A 2-Year Follow-Up Study
por: Wu, Chen-Jung, et al.
Publicado: (2023)

Correction: Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells
por: Tay, Rong En, et al.
Publicado: (2020)

Cellular prostatic acid phosphatase (cPAcP) serves as a useful biomarker of histone deacetylase (HDAC) inhibitors in prostate cancer cell growth suppression
por: Chou, Yu-Wei, et al.
Publicado: (2015)

LncRNA SNHG1 regulates neuroblastoma cell fate via interactions with HDAC1/2
por: Hsu, Chia-Lang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qir62551fq3rqmmtq1s263dokh