Hyperactive Somatostatin Interneurons Contribute to Excitotoxicity in Neurodegenerative Disorders

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping neurodegenerative disorders whose pathogenesis remains largely unknown. Here using TDP-43(A315T) mice, an ALS and FTD model with profound cortical pathology, we demonstrated that hyperactive somatostatin interneuro...

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Detalles Bibliográficos
Autores principales: Zhang, Wen, Zhang, Lifeng, Liang, Bo, Schroeder, David, Zhang, Zhong-wei, Cox, Gregory A., Li, Yun, Lin, Da-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811704/
https://www.ncbi.nlm.nih.gov/pubmed/26900927
http://dx.doi.org/10.1038/nn.4257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811704/
https://www.ncbi.nlm.nih.gov/pubmed/26900927
http://dx.doi.org/10.1038/nn.4257

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