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Hyperactive Somatostatin Interneurons Contribute to Excitotoxicity in Neurodegenerative Disorders
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping neurodegenerative disorders whose pathogenesis remains largely unknown. Here using TDP-43(A315T) mice, an ALS and FTD model with profound cortical pathology, we demonstrated that hyperactive somatostatin interneuro...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811704/ https://www.ncbi.nlm.nih.gov/pubmed/26900927 http://dx.doi.org/10.1038/nn.4257 |