A novel biosensor to study cAMP dynamics in cilia and flagella

The cellular messenger cAMP regulates multiple cellular functions, including signaling in cilia and flagella. The cAMP dynamics in these subcellular compartments are ill-defined. We introduce a novel FRET-based cAMP biosensor with nanomolar sensitivity that is out of reach for other sensors. To meas...

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Detalles Bibliográficos
Autores principales: Mukherjee, Shatanik, Jansen, Vera, Jikeli, Jan F, Hamzeh, Hussein, Alvarez, Luis, Dombrowski, Marco, Balbach, Melanie, Strünker, Timo, Seifert, Reinhard, Kaupp, U Benjamin, Wachten, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811770/
https://www.ncbi.nlm.nih.gov/pubmed/27003291
http://dx.doi.org/10.7554/eLife.14052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811770/
https://www.ncbi.nlm.nih.gov/pubmed/27003291
http://dx.doi.org/10.7554/eLife.14052

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