Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling

Polo-like kinase 1 (PLK1) is a key cell cycle regulator implicated in the development of various cancers, including prostate cancer. However, the functions of PLK1 beyond cell cycle regulation remain poorly characterized. Here, we report that PLK1 overexpression in prostate epithelial cells triggers...

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Detalles Bibliográficos
Autores principales: Wu, Jianguo, Ivanov, Andrei I, Fisher, Paul B, Fu, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811775/
https://www.ncbi.nlm.nih.gov/pubmed/27003818
http://dx.doi.org/10.7554/eLife.10734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811775/
https://www.ncbi.nlm.nih.gov/pubmed/27003818
http://dx.doi.org/10.7554/eLife.10734

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