Effects of berberine on pharmacokinetics of midazolam and rhodamine 123 in rats in vivo

AIM: To evaluate whether berberine hydrochloride (BBR) could modify the pharmacokinetic profiles of midazolam (MDZ), a substrate of CYP3A, and rhodamine 123 (Rh123), a substrate of P-glycolprotein (P-gp), in male rats. METHODS: The rats were given with varied does of BBR or 75 mg/kg ketoconazole as...

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Detalles Bibliográficos
Autores principales: Xin, Hua-Wen, Tang, Xia, Ouyang, Meng, Zhong, Jian-Xun, Li, Wei-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811842/
https://www.ncbi.nlm.nih.gov/pubmed/27066387
http://dx.doi.org/10.1186/s40064-016-2013-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811842/
https://www.ncbi.nlm.nih.gov/pubmed/27066387
http://dx.doi.org/10.1186/s40064-016-2013-z

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