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Effects of berberine on pharmacokinetics of midazolam and rhodamine 123 in rats in vivo

AIM: To evaluate whether berberine hydrochloride (BBR) could modify the pharmacokinetic profiles of midazolam (MDZ), a substrate of CYP3A, and rhodamine 123 (Rh123), a substrate of P-glycolprotein (P-gp), in male rats. METHODS: The rats were given with varied does of BBR or 75 mg/kg ketoconazole as...

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Detalles Bibliográficos
Autores principales:	Xin, Hua-Wen, Tang, Xia, Ouyang, Meng, Zhong, Jian-Xun, Li, Wei-Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811842/ https://www.ncbi.nlm.nih.gov/pubmed/27066387 http://dx.doi.org/10.1186/s40064-016-2013-z

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