Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest

Streptococcus pneumoniae produces pneumolysin toxin as a key virulence factor against host cells. Pneumolysin is a cholesterol-dependent cytolysin (CDC) toxin that forms lytic pores in host membranes and mediates pneumococcal disease pathogenesis by modulating inflammatory responses. Here, we show t...

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Detalles Bibliográficos
Autores principales: Rai, Prashant, He, Fang, Kwang, Jimmy, Engelward, Bevin P., Chow, Vincent T.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812240/
https://www.ncbi.nlm.nih.gov/pubmed/27026501
http://dx.doi.org/10.1038/srep22972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812240/
https://www.ncbi.nlm.nih.gov/pubmed/27026501
http://dx.doi.org/10.1038/srep22972

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