An atomistic view of Hsp70 allosteric crosstalk: from the nucleotide to the substrate binding domain and back

The Hsp70 is an allosterically regulated family of molecular chaperones. They consist of two structural domains, NBD and SBD, connected by a flexible linker. ATP hydrolysis at the NBD modulates substrate recognition at the SBD, while peptide binding at the SBD enhances ATP hydrolysis. In this study...

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Detalles Bibliográficos
Autores principales: Chiappori, Federica, Merelli, Ivan, Milanesi, Luciano, Colombo, Giorgio, Morra, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812256/
https://www.ncbi.nlm.nih.gov/pubmed/27025773
http://dx.doi.org/10.1038/srep23474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812256/
https://www.ncbi.nlm.nih.gov/pubmed/27025773
http://dx.doi.org/10.1038/srep23474

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