Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors

Here, we applied optoRAF, an optogenetic tool for light-controlled clustering and activation of RAF proteins that mimics the natural occurring RAS-mediated dimerization. This versatile tool allows studying the effect on BRAF and CRAF homodimer- as well as heterodimer-induced RAF signaling. Vemurafen...

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Detalles Bibliográficos
Autores principales: Chatelle, Claire V., Hövermann, Désirée, Müller, Anne, Wagner, Hanna J., Weber, Wilfried, Radziwill, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812324/
https://www.ncbi.nlm.nih.gov/pubmed/27025703
http://dx.doi.org/10.1038/srep23713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812324/
https://www.ncbi.nlm.nih.gov/pubmed/27025703
http://dx.doi.org/10.1038/srep23713

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