Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation

Prefoldin is a molecular chaperone complex that regulates tubulin function in mitosis. Here, we show that Prefoldin depletion results in disruption of neuroblast polarity, leading to neuroblast overgrowth in Drosophila larval brains. Interestingly, co-depletion of Prefoldin and Partner of Inscuteabl...

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Detalles Bibliográficos
Autores principales: Zhang, Yingjie, Rai, Madhulika, Wang, Cheng, Gonzalez, Cayetano, Wang, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812327/
https://www.ncbi.nlm.nih.gov/pubmed/27025979
http://dx.doi.org/10.1038/srep23735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812327/
https://www.ncbi.nlm.nih.gov/pubmed/27025979
http://dx.doi.org/10.1038/srep23735

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