Structure of the Cyclic Nucleotide-Binding Homology Domain of the hERG Channel and Its Insight into Type 2 Long QT Syndrome

The human ether-à-go-go related gene (hERG) channel is crucial for the cardiac action potential by contributing to the fast delayed-rectifier potassium current. Mutations in the hERG channel result in type 2 long QT syndrome (LQT2). The hERG channel contains a cyclic nucleotide-binding homology doma...

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Detalles Bibliográficos
Autores principales: Li, Yan, Ng, Hui Qi, Li, Qingxin, Kang, CongBao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812329/
https://www.ncbi.nlm.nih.gov/pubmed/27025590
http://dx.doi.org/10.1038/srep23712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812329/
https://www.ncbi.nlm.nih.gov/pubmed/27025590
http://dx.doi.org/10.1038/srep23712

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