Cargando…

Retargeting the Clostridium botulinum C2 toxin to the neuronal cytosol

Many biological toxins are known to attack specific cell types, delivering their enzymatic payloads to the cytosol. This process can be manipulated by molecular engineering of chimeric toxins. Using toxins with naturally unlinked components as a starting point is advantageous because it allows for t...

Descripción completa

Detalles Bibliográficos
Autores principales: Pavlik, Benjamin J., Hruska, Elizabeth J., Van Cott, Kevin E., Blum, Paul H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812341/
https://www.ncbi.nlm.nih.gov/pubmed/27025362
http://dx.doi.org/10.1038/srep23707