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Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma
The t(11;14) translocation resulting in constitutive cyclin D1 expression is an early event in mantle cell lymphoma (MCL) transformation. Patients with a highly proliferative phenotype produce cyclin D1 transcripts with truncated 3′UTRs that evade miRNA regulation. Here, we report the recurrence of...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812644/ https://www.ncbi.nlm.nih.gov/pubmed/27025456 http://dx.doi.org/10.1186/s13045-016-0260-7 |