Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation

BACKGROUND: Carbon nanotube (CNT) is used for various industrial purposes, but exhibits carcinogenic effects in experimental animals. Chronic inflammation in the respiratory system may participate in CNT-induced carcinogenesis. 8-Nitroguanine (8-nitroG) is a mutagenic DNA lesion formed during inflam...

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Detalles Bibliográficos
Autores principales: Hiraku, Yusuke, Guo, Feiye, Ma, Ning, Yamada, Tatsuhiko, Wang, Shumin, Kawanishi, Shosuke, Murata, Mariko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812657/
https://www.ncbi.nlm.nih.gov/pubmed/27026438
http://dx.doi.org/10.1186/s12989-016-0127-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812657/
https://www.ncbi.nlm.nih.gov/pubmed/27026438
http://dx.doi.org/10.1186/s12989-016-0127-7

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