Structure of the eukaryotic replicative CMG helicase and pumpjack motion

The CMG helicase is composed of Cdc45, Mcm2-7 and GINS. Here we report the structure of the S. cerevisiae CMG determined by cryo-EM at a resolution of 3.7–4.8 Å. The structure reveals that GINS and Cdc45 scaffold the N-tier of the helicase while enabling motion of the AAA+ C-tier. CMG exists in two...

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Detalles Bibliográficos
Autores principales: Yuan, Zuanning, Bai, Lin, Sun, Jingchuan, Georgescu, Roxana, Liu, Jun, O’Donnell, Michael E., Li, Huilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812828/
https://www.ncbi.nlm.nih.gov/pubmed/26854665
http://dx.doi.org/10.1038/nsmb.3170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812828/
https://www.ncbi.nlm.nih.gov/pubmed/26854665
http://dx.doi.org/10.1038/nsmb.3170

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