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Optimal multiple testing under a Gaussian prior on the effect sizes
We develop a new method for large-scale frequentist multiple testing with Bayesian prior information. We find optimal [Formula: see text]-value weights that maximize the average power of the weighted Bonferroni method. Due to the nonconvexity of the optimization problem, previous methods that accoun...
Autores principales: | Dobriban, Edgar, Fortney, Kristen, Kim, Stuart K., Owen, Art B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813057/ https://www.ncbi.nlm.nih.gov/pubmed/27046938 http://dx.doi.org/10.1093/biomet/asv050 |
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