Cargando…

TFE3 Alleviates Hepatic Steatosis through Autophagy-Induced Lipophagy and PGC1α-Mediated Fatty Acid β-Oxidation

Autophagy flux deficiency is closely related to the development of hepatic steatosis. Transcription factor E3 (TFE3) is reported to be a crucial gene that regulates autophagy flux and lysosome function. Therefore, we investigated the role of TFE3 in a cell model of hepatic steatosis. We constructed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiong, Jie, Wang, Kezhou, He, Jiangping, Zhang, Guangya, Zhang, Dandan, Chen, Fengling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813243/ https://www.ncbi.nlm.nih.gov/pubmed/26999124 http://dx.doi.org/10.3390/ijms17030387

Ejemplares similares

Tollip Deficiency Alters Atherosclerosis and Steatosis by Disrupting Lipophagy
por: Chen, Keqiang, et al.
Publicado: (2017)

Neohesperidin enhances PGC-1α-mediated mitochondrial biogenesis and alleviates hepatic steatosis in high fat diet fed mice
por: Wang, Si-wei, et al.
Publicado: (2020)

The S100 calcium-binding protein A6 plays a crucial role in hepatic steatosis by mediating lipophagy
por: Du, Qian, et al.
Publicado: (2023)

Lipophagy: Connecting Autophagy and Lipid Metabolism
por: Singh, Rajat, et al.
Publicado: (2012)

Lipophagy and Alcohol-Induced Fatty Liver
por: Yang, Li, et al.
Publicado: (2019)

Inhibition of stearoyl-coenzyme A desaturase 1 ameliorates hepatic steatosis by inducing AMPK-mediated lipophagy
por: Zhou, Youping, et al.
Publicado: (2020)

Hepatic PRMT1 ameliorates diet-induced hepatic steatosis via induction of PGC1α
por: Xu, Lu, et al.
Publicado: (2022)

Active autophagy but not lipophagy in macrophages with defective lipolysis
por: Goeritzer, Madeleine, et al.
Publicado: (2015)

The Expanding Role of Mitochondria, Autophagy and Lipophagy in Steroidogenesis
por: Bassi, Geetika, et al.
Publicado: (2021)

Stevia and Stevioside Attenuate Liver Steatosis through PPARα-Mediated Lipophagy in db/db Mice Hepatocytes
por: Park, Miey, et al.
Publicado: (2022)

Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway
por: Fang, Yunyun, et al.
Publicado: (2020)

Ufmylation on UFBP1 alleviates non-alcoholic fatty liver disease by modulating hepatic endoplasmic reticulum stress
por: Mao, Ziming, et al.
Publicado: (2023)

Ethanol‐induced steatosis involves impairment of lipophagy, associated with reduced Dynamin2 activity
por: Rasineni, Karuna, et al.
Publicado: (2017)

Nonalcoholic fatty liver disease experiences accumulation of hepatic liquid crystal associated with increasing lipophagy
por: Wang, Liyang, et al.
Publicado: (2020)

Intestinal Pgc1α ablation protects from liver steatosis and fibrosis
por: Piccinin, Elena, et al.
Publicado: (2023)

PPARδ attenuates hepatic steatosis through autophagy-mediated fatty acid oxidation
por: Tong, Lei, et al.
Publicado: (2019)

Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway
por: Wang, Yan, et al.
Publicado: (2019)

Involvement of Lipophagy and Chaperone-Mediated Autophagy in the Pathogenesis of Non-Alcoholic Fatty Liver Disease by Regulation of Lipid Droplets
por: Mastoridou, Eleftheria M., et al.
Publicado: (2023)

Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
por: Li, Liuran, et al.
Publicado: (2021)

TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress
por: Zhou, Kailiang, et al.
Publicado: (2020)

NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice
por: Xiong, Xiwen, et al.
Publicado: (2019)

Improving Lipophagy by Restoring Rab7 Cycle: Protective Effects of Quercetin on Ethanol-Induced Liver Steatosis
por: Lin, Hongkun, et al.
Publicado: (2022)

The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders
por: Zhang, Sheng, et al.
Publicado: (2022)

TFE3-Mediated Autophagy is Involved in Dopaminergic Neurodegeneration in Parkinson’s Disease
por: He, Xin, et al.
Publicado: (2021)

Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro
por: Li, Ting, et al.
Publicado: (2021)

SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity
por: Zhang, Tian, et al.
Publicado: (2019)

The Role of Lipophagy in the Development and Treatment of Non-Alcoholic Fatty Liver Disease
por: Grefhorst, Aldo, et al.
Publicado: (2021)

Proanthocyanidin Alleviates Liver Ischemia/Reperfusion Injury by Suppressing Autophagy and Apoptosis via the PPARα/PGC1α Signaling Pathway
por: Yao, Zhilu, et al.
Publicado: (2023)

Structural and functional adaptation of Haloferax volcanii TFEα/β
por: Blombach, Fabian, et al.
Publicado: (2018)

Defective Autophagy, Mitochondrial Clearance and Lipophagy in Niemann-Pick Type B Lymphocytes
por: Canonico, Barbara, et al.
Publicado: (2016)

Lifelong Aerobic Exercise Alleviates Sarcopenia by Activating Autophagy and Inhibiting Protein Degradation via the AMPK/PGC-1α Signaling Pathway
por: Liang, Jiling, et al.
Publicado: (2021)

PGC-1α alleviates mitochondrial dysfunction via TFEB-mediated autophagy in cisplatin-induced acute kidney injury
por: Yuan, Longhui, et al.
Publicado: (2021)

PGC-1α inhibits M2 macrophage polarization and alleviates liver fibrosis following hepatic ischemia reperfusion injury
por: Zhang, Yanting, et al.
Publicado: (2023)

Novel PPARα agonist MHY553 alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging
por: Kim, Seong Min, et al.
Publicado: (2017)

PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis
por: Leone, Teresa C, et al.
Publicado: (2005)

Hepatic MicroRNA Expression by PGC-1α and PGC-1β in the Mouse
por: Piccinin, Elena, et al.
Publicado: (2019)

Rev-erbα exacerbates hepatic steatosis in alcoholic liver diseases through regulating autophagy
por: Liu, Qingxue, et al.
Publicado: (2021)

Hypothalamic lipophagy and energetic balance
por: Singh, Rajat
Publicado: (2011)

A role for lipophagy in atherosclerosis
por: Laval, Thomas, et al.
Publicado: (2023)

Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease
por: Jiang, Yan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fvqqbu5scuq7ddlff3b7k5p9eb